Principle:

Angiotensin II plays an important role in regulating the hemodynamics and structure of the cardiovascular system. Most of the known effects of Ang II in adult tissues can be attributed to the angiotensin II type I(AT1) receptor. AT1 and AT2 receptors differ in pharmacological and biochemical properties and exhibit opposite effects on cardiovascular hemodynamics and cell growth. In addition, renin-angiotensin and nitric oxide production systems have been shown to interact in the regulation of cardiovascular function. AngII stimulates angiogenesis and increases microvessel density. In fact, angiotensin II is produced by the action of angiotensin-converting enzyme on angiotensinogen; C-terminal - histaminoyl-leucine cleavage.

Applications:

To study the effect of angiotensin and renin on cardiovascular diseases, angiotensin II receptor, and the effect of angiotensin on muscle cells.

Preservation and dissolution:

Soluble in water (25 mg/ml), the aqueous solution is clear and colorless solution. It can also be dissolved in organic solvents or aqueous solutions of pH5-8. It is hydrolyzed in a strong acid or pH > 9.5 solution. It can be filtered through a 0.22um filter to remove bacteria.

Dry powder should be sealed and stored at -20 ℃, the prepared solution can be stored at -20 ℃ for 2 months, and the solution should avoid repeated freezing and thawing.

Soluble in water, soluble in methanol, ethanol and propylene glycol, insoluble in ether and chloroform; The pH value in aqueous solution is 5-8; It is stable in neutral solution and easy to hydrolyze in case of strong acid and base. The sequence of amino acids is aspartyl, arginyl, valyl, tyrosyl, isoalucoyl, histaminoyl, prolyl, phenylalanine.

Angiotensin II is the most important component of angiotensin.

Angiotensin receptors are found in the body's vascular smoothing machine, in the cells of the adrenal cortex, in some parts of the brain, and in the cells of the heart and kidneys. Angiotensin II binds to angiotensin receptors and causes corresponding physiological effects. Angiotensin acts on the vascular smooth muscle, which can cause the whole body arteriole contraction and increase the arterial blood pressure. Angiotensin II is one of the most potent vasoconstricting substances known. It acts on peripheral blood tubes, constricts the veins, increases the amount of blood returned to the heart, acts on the center, and causes thirst.

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