Anti-SFTPC Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

SFTPC

Immunogen :

Recombinant protein of human SFTPC

Synonym :

SFTPC;BRICD6;PSP-C;SFTP2;SMDP2;SP-C

Isotype :

IgG

Gene ID :

6440

Clone No :

Swiss Port :

P11686

Molecular weight :

21kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC IF

Recommended dilution :

WB 1:500-2000. IHC 1:50-200. IF 1:50-200.

Subcellular location :

Secreted Extracellular space Surface film

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.