Canine CCL4 Elisa Kit

Species :

Canine

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

1 pg/ml

Detection Range :

19-1200 pg/ml

Assay Length :

2-2.5h

Sample Type :

Serum; Plasma; Cell culture supernatant.

Long Name :

Chemokine (C-C motif) ligand 4

Synonyms :

CCL4; ACT2; G-26; LAG1; HC21; MIP1b; MIP-1-beta; MIP1BMIP1-B; SCYA4; Chemokine C-C-Motif Ligand 4; Small Inducible Cytokine A4; Homologous To Mouse Mip-1b

Background :

CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.