Bovine Haptoglobin Elisa Kit

Species :

Bovine

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

510 pg/ml

Detection Range :

3-200 ng/ml

Assay Length :

2-2.5h

Sample Type :

Serum; Plasma; Cell culture supernatant.

Long Name :

Haptoglobin

Synonyms :

Hpt; HP; BP; HP2ALPHA2; Hp2-Alpha; HPA1S; Alpha-2-Macroglobulin; Zonulin

Background :

Haptoglobin is an acute phase glycoprotein that is an inactive member of the peptidase S1 family of serine proteases. It is secreted by multiple cell types and binds with high affinity to circulating Hemoglobin. Association of Haptoglobin with free Hemoglobin protects tissues from Hemoglobin-mediated oxidative damage and facilitates Hemoglobin clearance. In addition, Haptoglobin has anti-inflammatory properties that are independent of Hemoglobin binding. It inhibits prostaglandin synthesis, scavenges nitric oxide, dampens the inflammatory response to endotoxins, and inhibits T cell proliferation and neutrophil respiratory bursts. Deletion of Haptoglobin in mice facilitates the development of autoimmune inflammation.