Human SCGN Elisa Kit

Species :

Human

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

4 pg/ml

Detection Range :

7.8-500 pg/ml

Assay Length :

3.5h

Sample Type :

Serum; Plasma; Cell culture supernatant.

Long Name :

Secretagogin

Synonyms :

SCGN; CALBL; DJ501N12.8; SECRET; SEGN; setagin; secretagogin; EF-hand calcium binding protein

Background :

Secretagogin (SCGN) is a 32 kDa member of the EF-hand family of Ca-binding proteins. It is expressed in select neurons, as well as neuroendocrine cells and pancreatic islets. Human Secretagogin is 276 amino acids (aa) in length and contains six 35 aa EF-hand domains (aa 12?276). There is one alternative splice variant that shows a 22 aa substitution for aa 28?276, and which demonstrates no Ca-binding ability. Secretagogin is known to circulate, presumably released during cell apoptosis. Over aa 164?276, human Secretagogin is more than 97% aa identical to mouse, porcine and canine Secretagogin.