Human TIMP-1 Elisa Kit

No :   SEKH-0323
Size :   
Quantity :   
PRODUCT DESCRIPTION

Species :

Human

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

15 pg/ml

Detection Range :

31.2-2,000 pg/ml

Assay Length :

3.5h

Sample Type :

Serum; Plasma; Cell culture supernatant.

Long Name :

Tissue Inhibitors of Metalloproteinases 1

Synonyms :

TIMP1; CLGI; EPA; EPO; HCI; TIMP; TIMP-1; TIMP metallopeptidase inhibitor 1

Background :

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
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REFERENCE LIBRARY
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