Human CCL3 Elisa Kit


Product Description

Species: Human
Assay Type: Solid Phase Sandwich ELISA
Sensitivity: 15 pg/ml
Detection Range: 31.2-2,000 pg/ml
Assay Length: 3.5h
Sample Type: Serum; Plasma; Cell culture supernatant.
Long Name: Chemokine (C-C motif) ligand 3
Synonyms: CCL3; MIP1-A; MIP1A;MIP-1-alpha; SCYA3; G0S19-1; LD78ALPHA; Chemokine C-C-Motif Ligand 3; Small Inducible Cytokine A3; Homologous To Mouse Mip-1a; Tonsillar Lymphocyte LD78 Alpha Protein
Background: MIP-1 alpha (macrophage inflammatory protein 1 alpha) is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils. The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.
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REFERENCE LIBRARY

No:SEKH-0246
Size: