PRODUCT DESCRIPTION
Species :
HumanAssay Type :
Solid Phase Sandwich ELISASensitivity :
7 pg/mlDetection Range :
15.6-1,000 pg/mlAssay Length :
3.5hSample Type :
Serum; Plasma; Cell culture supernatant.Long Name :
Herpesvirus Entry MediatorSynonyms :
TNFRSF14; ATAR; CD270; HVEA; HVEM; LIGHTR; TR2; TNF receptor superfamily member 14Background :
HVEM/TNFRSF14 (herpesvirus entry mediator) is a transmembrane protein that is most highly expressed on na?ve, memory, and regulatory T cells but declines during T cell activation. It is present at low levels on most resting leukocytes. HVEM is a receptor for BTLA, CD160, and LIGHT. A cis interaction between HVEM and BTLA promotes cell survival, while trans interaction promotes a state of lymphocyte inactivity. LIGHT is expressed following T cell activation and competes with BTLA for HVEM binding, leading to a proinflammatory response. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding. Human, but not mouse, HVEM can also bind lymphotoxin-alpha.RELATED PRODUCTS
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REFERENCE LIBRARY
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