Human CTLA-4/CD152 Elisa Kit

Species :

Human

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

7 pg/ml

Detection Range :

15.6-1,000 pg/ml

Assay Length :

3.5h

Sample Type :

Serum; Plasma; Cell culture supernatant.

Long Name :

Cytotoxic T-lymphocyte-associated Molecule 4

Synonyms :

CTLA4; ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12; cytotoxic T-lymphocyte associated protein 4

Background :

CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation - a phenomenon which is particularly notable in cancers. It acts as an off switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
The CTLA-4 protein is encoded by the Ctla4 gene in mice and the CTLA4 gene in humans.