Anti-TGS1 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TGS1

Immunogen :

Recombinant protein of human TGS1

Synonym :

CLL associated antigen KW 2;HCA137;NCOA6IP;PIMT;PIPMT;TGS1;Trimethylguanosine synthase

Isotype :

IgG

Gene ID :

96764

Clone No :

Swiss Port :

Q96RS0

Molecular weight :

97kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC

Recommended dilution :

IHC 1:100-300.

Subcellular location :

Nucleus Cytoplasm?

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies . Plays a role in transcriptional regulation.