Anti-ABAT Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

ABAT

Immunogen :

Recombinant protein of human ABAT

Synonym :

ABAT;GABA aminotransferase;GABA AT;GABA T;GABA transaminase;GABAT;L AIBAT

Isotype :

IgG

Gene ID :

18

Clone No :

Swiss Port :

P80404

Molecular weight :

56kDa

Purification :

Affinity purification

Reactivity :

Mouse Rat

Application :

WB

Recommended dilution :

WB 1:1000-3000.

Subcellular location :

Cytoplasm?

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.?