Anti-AIM2 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

AIM2

Immunogen :

A synthetic peptide of Human AIM2

Synonym :

PYHIN4;absent in melanoma 2

Isotype :

IgG

Gene ID :

9447

Clone No :

Swiss Port :

O14862

Molecular weight :

39kDa

Purification :

Octanoic acid-ammonium sulfate precipitation

Reactivity :

Human

Application :

WB IHC

Recommended dilution :

WB 1:1000-3000. IHC 1:100-300.

Subcellular location :

Cytoplasm Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.