PRODUCT DESCRIPTION
Conjugation :
UnconjugateHost :
RabbitClonality :
Polyclonal AntibodyGene symbol :
NALP4Immunogen :
A synthetic peptide of human NALP4Synonym :
CT58;PAN2;PYPAF4Isotype :
IgGGene ID :
147945Clone No :
Swiss Port :
Q96MN2Molecular weight :
56/103/113kDaPurification :
Affinity purificationReactivity :
HumanApplication :
IHCRecommended dilution :
IHC 1:50-200.Subcellular location :
/Storage :
Store at -20°C. Avoid freeze / thaw cycles.Background :
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.RELATED PRODUCTS
No data
REFERENCE LIBRARY
No data