Anti-CLDN19 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CLDN19

Immunogen :

A synthetic peptide of human CLDN19

Synonym :

HOMG5; claudin-19

Isotype :

IgG

Gene ID :

149461

Clone No :

Swiss Port :

Q8N6F1

Molecular weight :

23kDa

Purification :

Affinity purification

Reactivity :

Human Rat

Application :

IHC

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Cell membrane Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.