Anti-PLAU Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

PLAU

Immunogen :

Recombinant protein of human PLAU

Synonym :

ATF;PLAU;U plasminogen activator;uPA;URK

Isotype :

IgG

Gene ID :

5328

Clone No :

Swiss Port :

P00749

Molecular weight :

49kDa

Purification :

Octanoic acid-ammonium sulfate precipitation

Reactivity :

Human Rat

Application :

WB IHC

Recommended dilution :

WB 1:5000-8000. IHC 1:50-200.

Subcellular location :

Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.