Anti-P4HB Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

P4HB

Immunogen :

A synthetic peptide of human P4HB

Synonym :

CLCRP1;DSI;ERBA2L;GIT;P4Hbeta;PDI;PDIA1;PHDB;PO4DB;PO4HB;PROHB

Isotype :

IgG

Gene ID :

5034

Clone No :

Swiss Port :

P07237

Molecular weight :

57kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

WB IHC

Recommended dilution :

WB 1:8000-12000. IHC 1:50-200.

Subcellular location :

Cell membrane Endoplasmic reticulum Endoplasmic reticulum lumen Melanosome Peripheral membrane protein

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.