Anti-TIMP1 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TIMP1

Immunogen :

A synthetic peptide of human TIMP1

Synonym :

ABH;ABH1;ALKBH;alkB;hABH

Isotype :

IgG

Gene ID :

7076

Clone No :

Swiss Port :

P01033

Molecular weight :

33kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

WB

Recommended dilution :

WB 1:3000.

Subcellular location :

Secreted

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.