Human NT-ProANP ELISA KIT

Species :

Human

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

15pg/ml

Detection Range :

31.25-2000pg/ml

Assay Length :

3h15min

Sample Type :

Serum, plasma, Cell culture supernatant

Long Name :

N-terminal proatrial natriuretic peptide

Synonyms :

ANP;ANF;ATFB6;ATRST2;CDD;CDD-ANF;CDP;PND

Background :

N-terminal proatrial natriuretic peptide (NT-proANP) is the biologically inactive fragment (98 amino acid) of the ANP prohormone. The secreted prohormone is cleaved producing the N-terminus fragment (NT-proANP) and the atrial natruiretic peptide (ANP). The natriuretic peptides have a common characteristic biochemical structure that consists of a ring of 17 amino acids and a disulfide bridge between 2 cysteine molecules. NT-proANP has been shown to be a useful diagnostic and prognostic tool in heart failure and myocardial infarction. NT-proANP is more stable and has a longer half-life in circulation than ANP. In patients with mild to moderate cardiac disease, NT-proANP levels were increased in response to atrial wall stress increase. Patients diagnosed with diastolic or systolic dysfunction had 2- to 3-fold higher NT-proANP than the control group. A recent study in rat showed that NT-proANP is an excellent biomarker for cardiac hypertrophy.