Anti-Bcl-6 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

Bcl-6

Immunogen :

A synthetic peptide of human Bcl-6

Synonym :

BCL6;BCL5;BCL6A;LAZ3;ZBTB27;ZNF51

Isotype :

IgG

Gene ID :

604

Clone No :

Swiss Port :

P41182

Molecular weight :

72/79kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

WB IHC

Recommended dilution :

WB 1:1000-3000. IHC 1:50-200.

Subcellular location :

Nucleus

Storage :

Store at -20℃. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.