Mouse BMP-3 ELISA KIT

Species :

Mouse

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

9.375pg/ml

Detection Range :

18.75-1200pg/ml

Assay Length :

3.5h

Sample Type :

Serum, plasma, Cell culture supernatant

Long Name :

Bone morphogenetic protein 3

Synonyms :

BMP3; BMP-3; BMP3A; BMP-3A; bone morphogenetic protein 3 (osteogenic); bone morphogenetic protein 3; Bone morphogenetic protein 3A; bone morphogenetic protein-3; Osteogenin

Background :

Bone morphogenetic protein 3 (BMP3) is a protein in Mouses that is encoded by the BMP3 gene.[1] The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density.[2] BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with activin receptor type 2b.[3] It is highly expressed in fractured tissues.[4] BMP3 is downregulated in cholangiocarcinoma (CC) and may act as a biomarker of the cancer.[5] Furthermore, promotor region methylation of the BMP3 gene may cause gastric carcinoma.[6]