Monkey IgE ELISA KIT

Species :

Monkey

Assay Type :

Solid Phase Sandwich ELISA

Sensitivity :

0.39ng/mL

Detection Range :

0.78-50ng

Assay Length :

3.5h

Sample Type :

Serum, plasma, Cell culture supernatant

Long Name :

Immunoglobulin E

Synonyms :

IgE；Immunoglobulin E

Background :

Immunoglobulin E (IgE) is a kind of antibody (or immunoglobulin (Ig) isotype) that has only been found in mammals. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgE's main function is immunity to parasites such as helminths[1] like Schistosoma mansoni, Trichinella spiralis, and Fasciola hepatica.[2] IgE is utilized during immune defense against certain protozoan parasites such as Plasmodium falciparum. IgE also has an essential role in type I hypersensitivity,[3] which manifests various allergic diseases, such as allergic asthma, most types of sinusitis, allergic rhinitis, food allergies, and specific types of chronic urticaria and atopic dermatitis. IgE also plays a pivotal role in responses to allergens, such as: anaphylactic drugs, bee stings, and antigen preparations used in desensitization immunotherapy. Although IgE is typically the least abundant isotype—blood serum IgE levels in a normal (non-atopic) individual are only 0.05% of the Ig concentration,[4] compared to 75% for the IgGs at 10 mg/ml, which are the isotypes responsible for most of the classical adaptive immune response—it is capable of triggering the most powerful inflammatory reactions. IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells and basophils. IgE may play an important role in the immune system’s recognition of cancer,[5] in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE is known to be elevated in various autoimmune disorders such as Lupus(SLE), Rheumatoid Arthritis(RA) & psoriasis, and is theorized to be of pathogenetic importance in RA and SLE by eliciting a hypersensitivity reaction.[6]