Anti-INDO Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

INDO

Immunogen :

Recombinant protein of human INDO

Synonym :

IDO;IDO-1;INDO;indoleamine 2

Isotype :

IgG

Gene ID :

3620

Clone No :

Swiss Port :

P14902

Molecular weight :

45kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB

Recommended dilution :

WB 1:1000-3000.

Subcellular location :

Cytoplasm

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.