Anti-TNK2 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TNK2

Immunogen :

A synthetic peptide of human TNK2

Synonym :

TNK2;ACK;ACK-1;ACK1;p21cdc42Hs

Isotype :

IgG

Gene ID :

10188

Clone No :

Swiss Port :

Q07912

Molecular weight :

60/115/116kDa

Purification :

Affinity purification

Reactivity :

Human Rat

Application :

IHC

Recommended dilution :

IHC 1:100-300.

Subcellular location :

Cytoplasm Cell membrane Nucleus

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.