Anti-USP18 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

USP18

Immunogen :

Recombinant protein of human USP18

Synonym :

43 kDa ISG15 specific protease;43 kDa ISG15-specific protease;EC 3.1.2.;hUBP43;Interferon Stimulated Gene 43 kD;ISG15 Specific Processing Protease;ISG15-specific-processing protease;ISG43;Ubiquitin Specific Peptidase 18;Ubiquitin Specific Protease 18 43 kD;Ubiquitin Specific Protease 18;Ubl carboxyl terminal hydrolase 18;Ubl carboxyl-terminal hydrolase 18;Ubl thioesterase 18;Ubl thiolesterase 18;Ubp15;UBP18_HUMAN;USP18;

Isotype :

IgG

Gene ID :

11274

Clone No :

Swiss Port :

Q9UMW8

Molecular weight :

41/43kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB

Recommended dilution :

WB 1:1000-3000.

Subcellular location :

Cytoplasm Nucleus

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.