Recombinant Cynomolgus TIM-3/HAVCR2

No :   P00890
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PRODUCT DESCRIPTION

Description :

Recombinant Cynomolgus T Cell Immunoglobulin and Mucin Domain-3 is produced by our Mammalian expression system and the target gene encoding Ser22-Arg201 is expressed with a 8His tag at the N-terminus.

Formulation :

Lyophilized from a 0.2 米m filtered solution of PBS, pH7.4.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin :

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Reconstitution :

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 米g/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Storage :

Lyophilized protein should be stored at < -20~C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7~C for 2-7 days.Aliquots of reconstituted samples are stable at < -20~C for 3 months.

Background :

T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
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