Anti-NMRAL1 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

NMRAL1

Immunogen :

Recombinant protein of human NMRAL1

Synonym :

FLJ25918;HSCARG;NmrA like family domain containing 1;NmrA like family domain containing protein 1;NmrA-like family domain-containing protein 1;NMRAL1;NMRL1_HUMAN;SDR48A1;

Isotype :

IgG

Gene ID :

57407

Clone No :

Swiss Port :

Q9HBL8

Molecular weight :

33kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC

Recommended dilution :

WB 1:1000-3000. IHC 1:50-200.

Subcellular location :

Cell membrane Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.