Anti-CFLAR Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CFLAR

Immunogen :

A synthetic peptide of human CFLAR

Synonym :

CASH;CASP8AP1;CLARP;Casper;FLAME;FLAME-1;FLAME1;FLIP;I-FLICE;MRIT;c-FLIP;c-FLIPL;c-FLIPR;c-FLIPS

Isotype :

IgG

Gene ID :

8837

Clone No :

Swiss Port :

O15519

Molecular weight :

25/31/41/51/55kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC

Recommended dilution :

IHC 1:50-200.

Subcellular location :

Cytoplasm Cell membrane

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.