Anti-WAC Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

WAC

Immunogen :

Recombinant protein of human WAC

Synonym :

BM-016;FLJ31290;MGC10753;PRO1741;Wwp4

Isotype :

IgG

Gene ID :

51322

Clone No :

Swiss Port :

Q9BTA9

Molecular weight :

71/65/59/48kDa

Purification :

Octanoic acid-ammonium sulfate precipitation

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:50-200.

Subcellular location :

Nucleus Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) ref. Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription ref. Regulates the cell-cycle checkpoint activation in response to DNA damage ref. Positive regulator of amino acid starvation-induced autophagy ref. Also acts as a negative regulator of basal autophagy ref. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation ref. May negatively regulate the ubiquitin proteasome pathway ref.