Anti-SARS-CoV/SARS-CoV-2 Nucleocapsid Monoclonal Antibody

Conjugation :

Unconjugation

Host :

Mouse

Clonality :

Monoclonal Antibody

Gene symbol :

SARS-CoV/SARS-CoV-2 Nucleocapsid

Immunogen :

Recombinant Protein

Synonym :

2019-nCoV Nucleocapsid;SARS-CoV-2 Nucleocapsid Protein;SARS-CoV-2 NP;2019-nCoV N;Coronavirus NP

Isotype :

IgG1

Gene ID :

43740575/1489678

Clone No :

1B8

Swiss Port :

P0DTC9/P59595

Molecular weight :

46kDa

Purification :

Affinity purification

Reactivity :

SARS-CoV SARS-CoV-2

Application :

WB Elisa

Recommended dilution :

WB 1:5000-8000. ELISA 1:5000-50000.

Subcellular location :

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.