Anti-ALPP/ALPG/ALPI Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

ALPP/ALPG/ALPI

Immunogen :

A synthetic peptide of Human ALPP/ALPG/ALPI

Synonym :

Alkaline phosphatase;Alkaline phosphatase placental;Alkaline phosphatase placental type;Alkaline phosphatase Regan isozyme;ALP;Alp1;ALPP;FLJ61142;Germ-cell alkaline phosphatase;nagao isozyme;OTTHUMP00000164354;PALP;Placental alkaline phosphatase 1;placental heat-stable alkaline phosphatase;placental type;PLAP;PLAP-1;PLAP1;PPB1_HUMAN;Akp5;Alkaline phosphatase;Alkaline phosphatase Nagao isozyme;Alkaline phosphatase placental like;ALP 1;ALP-1;ALP1;ALPG;ALPPL 2;ALPPL;ALPPL2;C77216;D1Ertd816e;GCAP;Germ cell alkaline phosphatase;Nagao isozyme;Placental alkaline phosphatase-like;Placental like alkaline phosphatase;placental-like;PLAP like;PLAP-like;PPBN_HUMAN;Testicular and thymus alkaline phosphatase;Alkaline Phosphatase/ALPP/ALPI

Isotype :

IgG

Gene ID :

250/251/248

Clone No :

Swiss Port :

P05187/P10696/P09923

Molecular weight :

57/58kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

WB IHC

Recommended dilution :

WB 1:2000-5000. IHC 1:50-200.

Subcellular location :

Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

ALPP (Alkaline phosphatase placental type; also SEAP, PALP-1 and ALP) is a 66-68 kDa glycoprotein member of the alkaline phosphatase family of molecules. It is principally expressed by 2nd and 3rd trimester synctiotrophoblasts and tumor cells, and represents one of four alkaline phosphatase isozymes. Experimentally, it cleaves phosphate monoesters into alcohol and phosphate. Human ALPP is synthesized as a 535 amino acid (aa) preproprecursor. It contains a 22 aa signal sequence, a 484 mature region (aa 23-506), and a 29 aa C-terminal propeptide that is cleaved to generate a GPI linkage at Asp506. The ALPP gene is highly allelic and may generate three potential splice variants that involve the signal sequence. The ALPP enzyme utilizes one Mg and two Zn ions, and functions as either a homodimer, or a heterodimer with the related Intestinal (ALPI) and Germ cell (GCAP) family members on the cell surface. ALPP is reported to oligomerize under certain conditions. Over aa 23-506, human ALPP shares 96% and 77% aa identity with chimpazeee ALPP and mouse embryonic-type alkaline phosphatase, respectively. It also shares 88% and 98% aa identity with IAP and GCAP, respectively. Over aa 23-506, human ALPP shares 86% aa identity with human ALPI.