Anti-TDG Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TDG

Immunogen :

A synthetic peptide of Human TDG

Synonym :

C JUN leucine zipper interactive protein;C JUN leucine zipper interactive protein;C-JUN leucine zipper interactive protein JZA-3;E130317C12Rik;EC 3.2.2.29;G/T mismatch specific thymine DNA glycosylase;G/T mismatch specific thymine DNA glycosylase;G/T mismatch-specific thymine DNA glycosylase;JZA 3;Jza1;T:G mismatch thymine glycosylase;Tdg;TDG_HUMAN;Thymine DNA glycosylase;Thymine-DNA glycosylase;

Isotype :

IgG

Gene ID :

6996

Clone No :

Swiss Port :

Q13569

Molecular weight :

46kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

WB

Recommended dilution :

WB 1:1000-3000.

Subcellular location :

Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.