Anti-TEAD3 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TEAD3

Immunogen :

A synthetic peptide of Human TEAD3

Synonym :

DTEF-1;ETFR-1;TEAD-3;TEAD5;TEF-5;TEF5;TEA domain transcription factor 3

Isotype :

IgG

Gene ID :

7005

Clone No :

Swiss Port :

Q99594

Molecular weight :

48kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

WB

Recommended dilution :

WB 1:1000-3000.

Subcellular location :

Nucleus Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.