Anti-TNFRSF11B Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TNFRSF11B

Immunogen :

A synthetic peptide of Human TNFRSF11B

Synonym :

OCIF;OPG;PDB5;TR1;TNF receptor superfamily member 11b

Isotype :

IgG

Gene ID :

4982

Clone No :

Swiss Port :

O00300

Molecular weight :

46kDa

Purification :

Octanoic acid-ammonium sulfate precipitation

Reactivity :

Human Mouse Rat

Application :

WB IHC

Recommended dilution :

WB 1:2000-5000. IHC 1:25-100.

Subcellular location :

Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.