Anti-PCNA Monoclonal Antibody

Conjugation :

Unconjugate

Host :

Mouse

Clonality :

Monoclonal Antibody

Gene symbol :

PCNA

Immunogen :

A synthetic peptide coupled to KLH

Synonym :

Proliferating Cell Nuclear Antigen;DNA polymerase delta auxiliary protein;PCNAR

Isotype :

IgG1

Gene ID :

5111

Clone No :

12D10

Swiss Port :

P12004

Molecular weight :

29kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC

Recommended dilution :

WB 1:2000-5000.
IHC 1:50-300.

Subcellular location :

Nucleus

Storage :

Store at -20℃. Avoid freeze / thaw cycles.

Background :

PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. It is found in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6 dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.