Anti-PRKAG1 Polyclonal Antibody

Conjugation :

Unconjugation

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

PRKAG1

Immunogen :

A synthetic peptide of Human PRKAG1

Synonym :

PRKAG1;AMPKG;5'-AMP-activated protein kinase subunit gamma-1

Isotype :

IgG

Gene ID :

5571

Clone No :

Swiss Port :

P54619

Molecular weight :

34/38/39kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC

Recommended dilution :

WB 1:2000-5000. IHC 1:50-200.

Subcellular location :

Nucleus Cytoplasm? Secreted

Storage :

Store at -20～C. Avoid freeze / thaw cycles.

Background :

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.