Anti-BCL2A1 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

BCL2A1

Immunogen :

Recombinant protein of human BCL2A1

Synonym :

GRS;BFL1;ACC-1;ACC-2;HBPA1;BCL2L5

Isotype :

IgG

Gene ID :

597

Clone No :

Swiss Port :

Q16548

Molecular weight :

20kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

WB

Recommended dilution :

WB 1:200-1000.

Subcellular location :

Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.