Anti-TLR3 Polyclonal Antibody

No :   K008081P
Size :   
Quantity :   
PRODUCT DESCRIPTION

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TLR3

Immunogen :

Recombinant protein of human TLR3

Synonym :

CD283;IIAE2;Toll-like receptor 3

Isotype :

IgG

Gene ID :

7098

Clone No :

Swiss Port :

O15455

Molecular weight :

73/104kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

WB IHC

Recommended dilution :

WB 1:500-2000. IHC 1:50-200.

Subcellular location :

Cytoplasm Early endosome Endoplasmic reticulum membrane Endosome membrane Single-pass type I membrane protein

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
RELATED PRODUCTS
No data
REFERENCE LIBRARY
No data