Anti-BAX Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

BAX

Immunogen :

Recombinant protein of human BAX

Synonym :

BCL2L4;Bax-protein;BAX_HUMAN;BAXA

Isotype :

IgG

Gene ID :

581

Clone No :

Swiss Port :

Q07812

Molecular weight :

21kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC ELISA

Recommended dilution :

WB 1:500-2000. IHC 1:25-100.

Subcellular location :

Cytoplasm Cytoplasm Mitochondrion membrane Single-pass membrane protein

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.