Anti-ANTXR1 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

ANTXR1

Immunogen :

Recombinant protein of human ANTXR1

Synonym :

ATR;GAPO;TEM8

Isotype :

IgG

Gene ID :

84168

Clone No :

Swiss Port :

Q9H6X2

Molecular weight :

63kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

IHC

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Cell membrane Cell projection Single-pass type I membrane protein filopodium membrane lamellipodium membrane

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.