Anti-HLA-DRA Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

HLA-DRA

Immunogen :

A synthetic peptide of human HLA-DRA

Synonym :

HLA-DRA1

Isotype :

IgG

Gene ID :

3122

Clone No :

Swiss Port :

P01903

Molecular weight :

29kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC

Recommended dilution :

IHC 1:50-100.

Subcellular location :

Cell membrane Endoplasmic reticulum membrane Endosome membrane Golgi apparatus Late endosome membrane Lysosome membrane Single-pass type I membrane protein trans-Golgi network membrane

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.