PRODUCT DESCRIPTION
Conjugation :
UnconjugateHost :
RabbitClonality :
Polyclonal AntibodyGene symbol :
DEPTORImmunogen :
A synthetic peptide of human DEPTORSynonym :
DEP.6;DEPDC6Isotype :
IgGGene ID :
64798Clone No :
Swiss Port :
Q8TB45Molecular weight :
46kDaPurification :
Affinity purificationReactivity :
Human MouseApplication :
WB IHCRecommended dilution :
WB 1:200-1000. IHC 1:10-100.Subcellular location :
CytoplasmStorage :
Store at -20°C. Avoid freeze / thaw cycles.Background :
DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.RELATED PRODUCTS
No data
REFERENCE LIBRARY
No data