Anti-CHM Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CHM

Immunogen :

A synthetic peptide of human CHM

Synonym :

TCD;GGTA;REP-1;DXS540;HSD-32

Isotype :

IgG

Gene ID :

1121

Clone No :

Swiss Port :

P24386

Molecular weight :

73/12kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC ELISA

Recommended dilution :

IHC 1: 20-100.

Subcellular location :

Cytoplasm cytosol

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.