Anti-CD5 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CD5

Immunogen :

A synthetic peptide of human CD5

Synonym :

T1;LEU1

Isotype :

IgG

Gene ID :

921

Clone No :

Swiss Port :

P06127

Molecular weight :

55kDa

Purification :

Affinity purification

Reactivity :

Human Mouse Rat

Application :

WB IHC

Recommended dilution :

WB 1:500-2000. IHC 1:30-150.

Subcellular location :

Cell membrane Single-pass type I membrane protein

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

CD5 (also designated Lyt-1) has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/ CD3-ζ chain and with the Src family kinase Lck p56. In vitro studies have shown a 10- to 15-fold increase in the kinase activity of Lck bound to CD5. The B cell antigen, CD72, serves as a receptor for CD5. The consequence of CD5 binding to its cognate receptor is still in question and likely plays a role in thymic selection. May act as a receptor in regulating T-cell proliferation.