Anti-XPC Polyclonal Antibody

No :   K007896P
Size :   
Quantity :   
PRODUCT DESCRIPTION

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

XPC

Immunogen :

A synthetic peptide of human XPC

Synonym :

XP3;RAD4;XPCC;p125

Isotype :

IgG

Gene ID :

7508

Clone No :

Swiss Port :

Q01831

Molecular weight :

102/16kDa

Purification :

Affinity purification

Reactivity :

Human Rat

Application :

IHC

Recommended dilution :

IHC 1:10-100.

Subcellular location :

Cytoplasm Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
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