Anti-CHD3 Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CHD3

Immunogen :

A synthetic peptide of human CHD3

Synonym :

ZFH;Mi-2a;Mi2-ALPHA

Isotype :

IgG

Gene ID :

1107

Clone No :

Swiss Port :

Q12873

Molecular weight :

223/227kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

WB IHC ELISA

Recommended dilution :

WB 1:500-2000. IHC 1: 50-100.

Subcellular location :

Cytoplasm Nucleus centrosome cytoskeleton microtubule organizing center

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.