Anti-CDKN2A Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CDKN2A

Immunogen :

A synthetic peptide of human CDKN2A

Synonym :

ARF;MLM;P14;P16;P19;CMM2;INK4;MTS1;TP16;CDK4I;CDKN2;INK4A;MTS-1;P14ARF;P19ARF;P16INK4;P16INK4A;P16-INK4A

Isotype :

IgG

Gene ID :

1029

Clone No :

Swiss Port :

P42771

Molecular weight :

17/11/14kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC

Recommended dilution :

IHC 1:50-200.

Subcellular location :

Cytoplasm Nucleus

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.