Anti-CTSC Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CTSC

Immunogen :

A synthetic peptide of human CTSC

Synonym :

JP;HMS;JPD;PLS;CPPI;DPP1;DPPI;PALS;DPP-I;PDON1

Isotype :

IgG

Gene ID :

1075

Clone No :

Swiss Port :

P53634

Molecular weight :

52kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

WB IHC

Recommended dilution :

WB 1:500-2000. IHC 1:50-200.

Subcellular location :

Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.