Anti-CBL Polyclonal Antibody

No :   K007681P
Size :   
Quantity :   
PRODUCT DESCRIPTION

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

CBL

Immunogen :

A synthetic peptide of human CBL

Synonym :

CBL2;NSLL;C-CBL;RNF55;FRA11B

Isotype :

IgG

Gene ID :

867

Clone No :

Swiss Port :

P22681

Molecular weight :

100kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

WB

Recommended dilution :

WB 1:500-2000.

Subcellular location :

Cell membrane Cytoplasm

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder
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REFERENCE LIBRARY
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