Anti-TEK Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

TEK

Immunogen :

A synthetic peptide of human TEK

Synonym :

CD202B;GLC3E;TIE-2;TIE2;VMCM;VMCM1

Isotype :

IgG

Gene ID :

7010

Clone No :

Swiss Port :

Q02763

Molecular weight :

126/109kDa

Purification :

Affinity purification

Reactivity :

Human Mouse

Application :

IHC

Recommended dilution :

IHC 1:50-200.

Subcellular location :

Cell junction Cell membrane Cytoplasm Secreted Single-pass type I membrane protein cytoskeleton focal adhesion

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.