Anti-PLAT Polyclonal Antibody

Conjugation :

Unconjugate

Host :

Rabbit

Clonality :

Polyclonal Antibody

Gene symbol :

PLAT

Immunogen :

A synthetic peptide of human PLAT

Synonym :

TPA;T-PA

Isotype :

IgG

Gene ID :

5327

Clone No :

Swiss Port :

P00750

Molecular weight :

63kDa

Purification :

Affinity purification

Reactivity :

Human

Application :

IHC

Recommended dilution :

IHC 1:25-100.

Subcellular location :

Secreted extracellular space

Storage :

Store at -20°C. Avoid freeze / thaw cycles.

Background :

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.